@article {961511,
	title = {Environment-Wide Association Study of Blood Pressure in the National Health and Nutrition Examination Survey (1999-2012)},
	journal = {Sci Rep},
	volume = {6},
	number = {30373},
	year = {2016},
	note = {PMC Free Full Text},
	month = {Jul 26 2016},
	pages = {1-8},
	abstract = {Identifying environmental exposures associated with blood pressure is a priority. Recently, we proposed the environment-wide association study to search for and replicate environmental factors associated with phenotypes. We conducted the environment-wide association study (EWAS) using the National Health and Nutrition Examination Surveys (1999{\textendash}2012) which evaluated a total of 71,916 participants to prioritize environmental factors associated with systolic and diastolic blood pressure. We searched for factors on participants from survey years 1999{\textendash}2006 and tentatively replicated findings in participants from years 2007{\textendash}2012. Finally, we estimated the overall association and performed a second meta-analysis using all survey years (1999{\textendash}2012). For systolic blood pressure, self-reported alcohol consumption emerged as our top finding (a 0.04 increase in mmHg of systolic blood pressure for 1 standard deviation increase in self-reported alcohol), though the effect size is small. For diastolic blood pressure, urinary cesium was tentatively replicated; however, this factor demonstrated high heterogeneity between populations (I2 = 51\%). The lack of associations across this wide of an analysis raises the call for a broader search for environmental factors in blood pressure.},
	url = {https://dx.doi.org/10.1038/srep30373},
	author = {McGinnis, Denise P and Brownstein, John S and Patel, Chirag J}
}
